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How much memory can an HPE ProLiant DL380 Gen10 hold? Up to 3 TB of DRAM with LRDIMMs, 1.54 TB with RDIMMs, or as much as 6 TB using Intel Optane Persistent Memory — with two fine-print items (your CPU model and your DIMM type) deciding which ceiling applies to you.
Last updated: 2026
The DL380 Gen10 provides 12 DIMM slots per processor — 24 slots in a dual-CPU server — and its maximum memory depends on which module type fills them. Here are the ceilings for a dual-processor configuration, followed by the caveats that determine whether your specific server can reach them.
| Module type | Maximum (dual CPU) | Configuration |
|---|---|---|
| LRDIMM | 3.0 TB | 24 × 128 GB modules |
| RDIMM | 1.54 TB | 24 × 64 GB modules |
| Intel Optane Persistent Memory | 6.0 TB (PMem) | 12 × 512 GB modules, alongside DRAM |
Load Reduced memory: 3.0 TB
LRDIMMs enable the platform's largest DRAM configuration: twenty-four 128 GB modules for 3.0 TB total, using DDR4-2666 (815102-B21) with 1st Generation Intel Xeon Scalable processors or DDR4-2933 (P00928-B21) with 2nd Generation.
Registered memory: 1.54 TB
With RDIMMs — the standard, most economical type — the ceiling is twenty-four 64 GB modules (P00930-B21) for 1.54 TB. In practice, most DL380 Gen10 upgrades use the popular 32 GB module, P00924-B21, which balances capacity and cost. Remember that RDIMMs and LRDIMMs cannot be mixed in the same server, so the module type you already have usually decides your path.
Intel Optane Persistent Memory: up to 6.0 TB
Servers with select 2nd Generation Intel Xeon Scalable processors can use Intel Optane Persistent Memory: twelve 512 GB modules (835810-B21) for 6.0 TB of persistent memory, installed in DIMM slots alongside conventional DRAM (PMem configurations always pair with regular DIMMs; the remaining slots carry the DRAM). This was the platform's headline number for in-memory database workloads. Note that 1st Generation CPUs do not support Optane PMem at all.
The fine print: your CPU sets the real ceiling
Every Xeon Scalable model has a per-socket memory limit, and the platform maximums above assume processors rated for large memory. Standard 1st Generation SKUs support 768 GB per socket (1.5 TB dual), with "M"-suffix models required for more; 2nd Generation standard SKUs support 1 TB per socket, with "L" models rated for the largest and Optane-heavy configurations. So before buying toward a 3 TB or 6 TB target, check your exact processor model in iLO. Also confirm your platform: the DL380 Gen10 Plus is a different server (3rd Generation Xeon, DDR4-3200) with its own memory list. For DIMM type, speed, and population rules on this platform family, see our companion guide to what memory is compatible with DL360 Gen10 servers — the same rules apply to the DL380 — and our explainer on memory rank for the RDIMM/LRDIMM architecture behind the limits.
Frequently asked questions
What is the maximum memory for an HPE DL380 Gen10?
Up to 3.0 TB of DRAM using twenty-four 128 GB LRDIMMs in a dual-processor server, or up to 6.0 TB of Intel Optane Persistent Memory using twelve 512 GB modules alongside DRAM, on servers with select 2nd Generation Intel Xeon Scalable processors. With standard RDIMMs the maximum is 1.54 TB.
How many memory slots does a DL380 Gen10 have?
Twelve DIMM slots per processor, for 24 slots in a dual-CPU configuration. A single-processor server can use only the 12 slots belonging to the installed CPU.
What is the maximum memory with RDIMMs?
1.54 TB, using twenty-four 64 GB registered modules. The 32 GB RDIMM is the most popular upgrade module for this platform, and RDIMMs cannot be mixed with LRDIMMs in the same server.
How does the DL380 Gen10 reach 6 TB?
With Intel Optane Persistent Memory: twelve 512 GB PMem modules installed in DIMM slots alongside conventional DRAM, on servers with select 2nd Generation Intel Xeon Scalable processors. 1st Generation processors do not support Optane PMem.
Can every DL380 Gen10 reach 3 TB of DRAM?
No. Each Xeon Scalable model has a per-socket memory limit: standard 1st Generation processors support 768 GB per socket, with M-suffix models required for more, and standard 2nd Generation processors support 1 TB per socket, with L models rated for the largest configurations. Check your exact CPU model in iLO before planning a maximum-memory build.
Is DL380 Gen10 Plus memory the same as DL380 Gen10 memory?
No. The Gen10 Plus is a separate platform with 3rd Generation Xeon Scalable processors and DDR4-3200 memory, ordered from its own option list. Confirm which platform you have before purchasing.
The bottom line
For a dual-CPU DL380 Gen10: 1.54 TB with RDIMMs, 3.0 TB with LRDIMMs, up to 6.0 TB with Optane Persistent Memory on supported 2nd Gen processors — always subject to your CPU model's per-socket limit. Browse genuine HPE ProLiant DL380 Gen10 memory options, check HPE's DL380 Gen10 memory configuration guide and Server Memory Configurator, see memory for every ProLiant on our HPE server memory pages, or contact our team and we'll confirm the right genuine HPE SmartMemory for your exact processors before you order.
