HPE ProLiant DL385 Gen10 Processors
Genuine HPE-qualified AMD EPYC processor kits for the HPE ProLiant DL385 Gen10, new and refurbished, alongside the heat sink and fan kits they need. This is a system-on-chip design with no separate chipset, and the QuickSpecs list the EPYC 7xx2 (7002) family from 8 to 64 cores.
DL385 Gen10 Processor Specifications
- Sockets: one or two — mixing two different processor models is not supported
- Range: 8 cores (EPYC 7252, 7262) through 64 cores (EPYC 7702), at 120W, 155W, 180W, and 200W
- Cache: 64MB on the 120W parts (7252, 7272, 7282), 128MB or 192MB across the mid-range, and 256MB on the 7532 and 7702
- SKU rule: the -L21 kit is the first processor and the -B21 kit is the second, and it ships with two additional fans
- Cooling: processors above 180W use the High Performance heat sink and require the High Performance fan kit; a 4LFF mid-tray caps CPU selection at 125W
- Memory support: every EPYC processor here supports up to 2TB per socket, and DDR4-2933 kits require a 7xx2 processor
Buy a matched pair, not two similar CPUs. Mixing two different processor models is not supported in the DL385 Gen10, and the second socket takes the -B21 kit, which ships with two additional fans. Anything above 180W also needs the High Performance heat sink and the High Performance fan kit.
Which processors does the DL385 Gen10 support?
| Tier | Examples | Best for |
|---|---|---|
| 8 to 16 cores | EPYC 7252, 7262, 7272, 7282, 7302 | High clocks and per-core licensed software |
| 24 to 32 cores | EPYC 7352, 7402, 7452, 7502, 7532 | General-purpose virtualization hosts |
| 48 to 64 cores | EPYC 7552, 7702 | Maximum consolidation density in 2U |
Two 64-core EPYC 7702 processors put 128 cores in 2U — the reason this chassis became a virtualization workhorse. Both of those are 200W parts, so plan for the High Performance heat sink and fan kit, and size power accordingly.
Choosing the Right DL385 Gen10 Processors
- Both processors must be identical — HPE does not allow mixing two different models, so match the installed CPU exactly when adding a second.
- The second CPU unlocks more than cores: 16 additional DIMM slots and both the secondary and tertiary PCIe risers depend on it.
- Order cooling with the CPU: anything above 180W needs the High Performance heat sink and fan kit, and the -B21 second-processor kit brings two extra fans with it.
- The CPU generation sets your memory grade: DDR4-2933 kits are supported only on 7xx2 processors — see DL385 Gen10 memory.
- Watch the chassis limits: selecting the 4LFF mid-plane carrier restricts you to processors of 125W or lower.
Complete Your DL385 Gen10 Build
Every added processor unlocks 16 more DIMM slots: see DL385 Gen10 memory, then drives, storage controllers, networking adapters, and power supplies, or the full DL385 Gen10 parts page. Related platforms: DL385 Gen10 Plus processors and the Intel-based DL380 Gen10 processors. Catalog-wide: HPE parts by server model.
DL385 Gen10 Processors FAQ
What processors does the HPE ProLiant DL385 Gen10 support?
One or two AMD EPYC processors. The QuickSpecs list the 7xx2 (7002) family: 7252, 7262, 7272, 7282, 7302, 7352, 7402, 7452, 7502, 7532, 7552, and the 64-core 7702, at 120W to 200W.
What is the maximum core count of the DL385 Gen10?
128 cores - two 64-core EPYC 7702 processors, each a 200W part with 256MB of cache. That is the densest configuration the QuickSpecs list for this 2U chassis.
What is the difference between the -L21 and -B21 processor kits?
Position. The -L21 kit is the first processor in the server and the -B21 kit is the second, which also ships with two additional fans for factory or field installation. Both must be the same processor model.
Can I mix two different AMD EPYC processors in a DL385 Gen10?
No. HPE states that mixing two different processor models is not allowed. When adding a second CPU, match the installed model exactly.
Do DL385 Gen10 processors need a special heat sink?
It depends on wattage. Processors above 180W ship with the High Performance heat sink and require the High Performance fan kit, which replaces all six fans. Lower-wattage parts use the standard heat sink.
What does adding a second processor to a DL385 Gen10 unlock?
16 more DIMM slots for 32 total, plus the secondary and tertiary PCIe risers, which are only available on a two-processor system. It also enables the onboard NVMe connections used by some drive cage options.
✅ Looking for a specific DL385 Gen10 processor? Browse our full selection below.
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