HPE ProLiant DL380 Gen10 Memory

Upgrade your HPE ProLiant DL380 Gen10 server with genuine HPE DDR4 memory. This dual-socket platform runs 1st and 2nd Generation Intel® Xeon® Scalable processors across 24 DIMM slots, supporting Registered (RDIMM) and Load-Reduced (LRDIMM) modules — plus Intel® Optane™ Persistent Memory and HPE NVDIMMs — and every module we sell is guaranteed compatible with your DL380 Gen10.

DL380 Gen10 Memory Specifications

• Memory type: HPE DDR4 SmartMemory — Registered ECC (RDIMM) and Load-Reduced ECC (LRDIMM). Also supports Intel Optane Persistent Memory (2nd Gen Xeon only) and HPE NVDIMM-N (1st Gen Xeon only). Unbuffered (UDIMM) memory is not supported.
• Speeds: up to 2666 MT/s with 1st Generation Intel Xeon Scalable processors, and up to 2933 MT/s with 2nd Generation — actual speed depends on the installed CPU and configuration.
• DIMM slots: 24 total (12 per processor; 6 memory channels per processor, 2 DIMMs per channel).
• Module capacities: RDIMM in 8GB, 16GB, 32GB, and 64GB; LRDIMM in 64GB and 128GB; HPE NVDIMM-N 16GB; Intel Optane Persistent Memory in 128GB, 256GB, and 512GB.
• Maximum memory: up to 1.5TB with RDIMMs (24 × 64GB) or 3.0TB with LRDIMMs (24 × 128GB), and up to 6TB using Intel Optane Persistent Memory on supported 2nd Gen Xeon processors. The ceiling your server can actually reach also depends on your processor's per-socket memory limit.

Before you order, match your memory to your processors. On the DL380 Gen10, memory speed is set by your CPU generation: 1st Generation Intel Xeon Scalable runs DDR4 at up to 2666 MT/s, while 2nd Generation reaches 2933 MT/s — and a faster DIMM installed in a slower system simply runs at the lower speed. Do not mix RDIMMs and LRDIMMs in the same server (it will not POST), and for best performance populate memory in balanced sets across both processors following HPE's population order. Intel Optane Persistent Memory requires a supported 2nd Generation Xeon, and HPE NVDIMMs require a 1st Generation Xeon.

Choosing & Populating DL380 Gen10 Memory

The right module type depends on your capacity and budget goals. RDIMMs are the standard, most economical choice and scale to 1.5TB (24 × 64GB). LRDIMMs enable the platform's largest DRAM configuration, reaching 3.0TB with 128GB modules, and are the better path when you need maximum capacity. Intel Optane Persistent Memory pairs with 2nd Generation Xeon processors to add a large, cost-effective memory tier of up to 6TB for in-memory databases and analytics, and can be mixed with either RDIMMs or LRDIMMs.

For best performance, populate DIMMs in balanced sets — ideally one per channel (6 per CPU) or all 12 slots per CPU — and keep both processors populated identically. Because RDIMMs and LRDIMMs cannot be mixed and certain modules (such as the 128GB 8R 3DS LRDIMM) have their own mixing restrictions, we recommend using HPE SmartMemory throughout for validated performance and full iLO reporting. For the complete DIMM slot maps and mixing rules, see HPE's official population guide:

HPE Gen10 Server Memory Population Rules (PDF)

DL380 Gen10 Memory FAQ

What memory is compatible with the HPE DL380 Gen10?
HPE DDR4 SmartMemory in Registered (RDIMM) or Load-Reduced (LRDIMM) form, all ECC. The platform also supports Intel Optane Persistent Memory with 2nd Generation Xeon processors and HPE NVDIMM-N with 1st Generation Xeon processors. Unbuffered (UDIMM) memory is not supported.

How much memory can the DL380 Gen10 hold?
Up to 1.5TB with RDIMMs (24 × 64GB) or 3.0TB with LRDIMMs (24 × 128GB), and up to 6TB using Intel Optane Persistent Memory on supported 2nd Gen Xeon processors. The maximum you can reach also depends on your specific CPU's per-socket memory limit.

What memory speed does the DL380 Gen10 run at?
Up to 2666 MT/s with 1st Generation Intel Xeon Scalable processors and up to 2933 MT/s with 2nd Generation. Speed is capped by the CPU, and mixing different speeds runs the whole system at the slowest module installed.

Can I mix RDIMMs and LRDIMMs, and do I need HPE memory?
No — RDIMMs and LRDIMMs must not be mixed in the same server, or it will not POST. Third-party DDR4 will physically work, but we recommend HPE SmartMemory so modules are validated for full speed, RAS features, and iLO predictive-failure reporting.

✅ Need help finding the right DL380 Gen10 memory? Browse our full selection above, or contact our HPE specialists for a guaranteed-compatible recommendation.

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