HPE ProLiant DL380 Gen10 Plus Drives

Genuine HPE hot-plug drives for the HPE ProLiant DL380 Gen10 Plus, new and refurbished, tested before shipping. This is the generation where U.3 tri-mode arrived on the DL380 — cage kits determine whether each SFF bay runs NVMe, SAS, or SATA, alongside classic LFF capacity configurations.

DL380 Gen10 Plus Drive Specifications

• SFF cage types: 8SFF U.2 NVMe, 8SFF U.3 x4/x2 tri-mode, 8SFF U.3 x1 tri-mode, and 8SFF SAS/SATA — the cage sets what each bay supports
• Maximums: up to 30 SFF (24+8+6 SATA / 24+2 SAS configurations) or up to 20 LFF (12+4+4 with mid-tray and rear cages)
• Top capacities: 15.36TB NVMe and SAS SSDs (nearly 400TB total SFF), 18TB LFF spindles (360TB total)
• Interfaces: NVMe (U.2 and U.3), SAS 12G, SATA 6G
• SSD endurance classes: Read Intensive and Mixed Use

The cage decides what fits. DL380 Gen10 Plus SFF bays come as U.2 NVMe, U.3 tri-mode, or SAS/SATA cages — a drive only works in a bay whose cage supports its interface, so identify your cage kit before ordering drives.

What drives fit the DL380 Gen10 Plus?

Confused by U.2 vs U.3? Our U.2 vs U.3 guide explains exactly how the two differ and why the cage type matters on this platform.

Choosing the Right DL380 Gen10 Plus Drives

• Know your cage before ordering: a U.2 NVMe cage takes NVMe only, U.3 tri-mode cages take all three interfaces, and SAS/SATA cages take no NVMe.
• Never mix interfaces or endurance classes within one RAID array — build arrays from identical drives.
• Match endurance to workload: Read Intensive for read-heavy serving, Mixed Use for databases — our DWPD guide explains the classes.
• Deciding between drive families? Start with how to choose the right HPE SSD.

Complete Your DL380 Gen10 Plus Build

Drives pair with DL380 Gen10 Plus storage controllers and the rest of the platform: memory, processors, networking, power supplies, or the full DL380 Gen10 Plus parts page. Neighboring generations: DL380 Gen10 drives and DL380 Gen11 drives. Browse the wider catalog at all HPE server SSDs, U.3 SSDs, and parts by server model.

DL380 Gen10 Plus Drives FAQ

Does the HPE ProLiant DL380 Gen10 Plus support NVMe drives?
Yes - through U.2 NVMe cages and U.3 tri-mode cages. The U.3 cages are the flexible choice: each bay can run NVMe, SAS, or SATA depending on the cage's tri-mode wiring.

How many drives fit in a DL380 Gen10 Plus?
Up to 30 SFF drives (24 front plus rear cage options) or up to 20 LFF (12 front + 4 mid-tray + 4 rear), depending on the cage configuration.

What is the difference between U.2 and U.3 drives?
U.3 is the tri-mode evolution of U.2: the same 2.5-inch form factor, but U.3 backplanes can run NVMe, SAS, or SATA through one connector. On the Gen10 Plus, the cage type determines which drives each bay accepts - our U.2 vs U.3 guide covers the details.

Can I use drives from a DL380 Gen10 in the Gen10 Plus?
Check the part number against the Gen10 Plus QuickSpecs first. SFF SAS/SATA drives generally carry across on their carriers, but the Gen10 Plus adds U.3 bays the Gen10 never had, and drive support lists differ by generation.

What's the difference between Read Intensive and Mixed Use SSDs?
Endurance. Read Intensive drives are rated around 1 drive write per day and cost less per TB; Mixed Use drives are rated around 3 DWPD for write-heavy databases and virtualization. Match the class to your workload and never mix classes in one array.

✅ Looking for a specific DL380 Gen10 Plus drive? Browse our full selection below.

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