HPE ProLiant DL380 Gen12 Drives

Genuine HPE hot-plug drives for the HPE ProLiant DL380 Gen12, new and refurbished, tested before shipping. This is the rare Gen12 platform that spans every drive format: 2.5-inch SFF U.3 bays on Basic Carriers, 3.5-inch LFF bays for capacity spindles, and EDSFF E3.S bays for dense NVMe flash.

DL380 Gen12 Drive Specifications

• Bay types by chassis: SFF (U.3, Basic Carrier), LFF, and EDSFF E3.S — the CTO chassis (8SFF/24SFF, 8LFF/12LFF, EDSFF) sets which bays you have
• Maximums: up to 30 SFF (24 + 6), up to 20 LFF (12 + 4 + 4), or up to 36 EDSFF drives
• Top capacities per class: 30.72TB NVMe (over 1PB total in a 36-bay EDSFF build), 24TB LFF SAS/SATA spindles, 15.36TB SFF SAS SSDs
• Interfaces: NVMe (U.3 and E3.S), SAS 12G, SATA 6G
• SSD endurance classes: Read Intensive (about 1 drive write per day) and Mixed Use (about 3 DWPD)
• HDDs: Mission Critical 10K SAS SFF plus Business Critical LFF SAS/SATA midline drives
• Carriers: Gen12 uses the Basic Carrier (BC) — Smart Carrier (SC) drives from Gen8–Gen10 servers do not fit

Check the carrier before you buy. DL380 Gen12 bays take Basic Carrier (BC) and EDSFF E3.S drives only — Smart Carrier (SC) drives from Gen8–Gen10 servers do not fit — and your chassis (SFF, LFF, or EDSFF) sets which drive format you can use at all.

What drives fit the DL380 Gen12?

LFF chassis carry the cheapest terabytes for backup and bulk storage; SFF U.3 keeps NVMe, SAS, and SATA options open in the same bays through the x1 and x4 tri-mode cage kits; EDSFF E3.S is the density play — our EDSFF E3.S guide explains why HPE is moving flash to this format.

Choosing the Right DL380 Gen12 Drives

• Never mix interfaces, endurance classes, or drive types within one RAID array — build arrays from identical drives.
• Match endurance to workload: Read Intensive for read-heavy serving, Mixed Use for databases — our DWPD guide explains the classes.
• Boot from the NS204i-u V2 module (dual-NVMe RAID1) instead of spending data bays on the OS.
• Check the carrier before reusing older drives: Smart Carrier drives from Gen10 and earlier are mechanically incompatible — here's why HPE moved off Smart Carriers.
• Buying genuine matters: our guide to genuine HPE vs third-party drives covers firmware, iLO reporting, and what actually happens with off-brand disks.

Complete Your DL380 Gen12 Build

Drives pair with DL380 Gen12 storage controllers and the rest of the platform: memory, processors, networking, power supplies, or the full DL380 Gen12 parts page. Previous generation: DL380 Gen11 drives. Browse the wider catalog at all HPE server SSDs, EDSFF NVMe SSDs, U.3 SSDs, and parts by server model.

DL380 Gen12 Drives FAQ

Does the HPE ProLiant DL380 Gen12 support 3.5-inch LFF drives?
Yes - unlike most Gen12 platforms, the DL380 Gen12 offers LFF chassis configurations with up to 20 LFF bays (12+4+4), taking SAS and SATA drives up to 24TB each for capacity-per-dollar builds.

How many drives fit in a DL380 Gen12?
Up to 30 SFF (24-bay front plus 6 more), up to 20 LFF, or up to 36 EDSFF E3.S drives, depending on the chassis configuration. A fully loaded EDSFF build with 30.72TB drives exceeds 1PB of flash in 2U.

Can I use drives from a Gen9 or Gen10 ProLiant in the DL380 Gen12?
No - those generations use the Smart Carrier (SC) tray, while Gen12 bays take Basic Carrier (BC) and EDSFF drives. Drives must be sourced in the correct Gen12 carrier.

What's the difference between Read Intensive and Mixed Use SSDs?
Endurance. Read Intensive drives are rated around 1 drive write per day and cost less per TB; Mixed Use drives are rated around 3 DWPD for write-heavy databases and virtualization. Match the class to your workload and never mix classes in one array.

Are HPE Multi Vendor SSDs genuine HPE drives?
Yes. Multi Vendor (MV) SSDs are HPE-qualified, HPE-firmware drives sourced from multiple flash manufacturers for better availability and price. They carry HPE part numbers and full DL380 Gen12 compatibility.

Do DL380 Gen12 NVMe drives need a RAID controller?
Not necessarily. NVMe drives can run direct-attached with Intel VROC software RAID, or through a tri-mode MR controller (MR416i family, or the PCIe Gen5 MR932i-p for SSD-only arrays) when you want hardware RAID.

✅ Looking for a specific DL380 Gen12 drive? Browse our full selection below.

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