HPE ProLiant DL380 Gen12 Drives

Upgrade your HPE ProLiant Compute DL380 Gen12 server with genuine hot-plug drives. HPE's flagship 2U dual-socket Intel® Xeon® 6 platform supports 2.5-inch (SFF), 3.5-inch (LFF), and EDSFF (E3.S) drives across SAS, SATA, and NVMe interfaces — and every drive we sell is guaranteed compatible with your DL380 Gen12.

DL380 Gen12 Drive Specifications

• Form factors & bays: 2.5-inch SFF (up to 30 hot-plug bays), 3.5-inch LFF (up to 20 bays), and E3.S EDSFF NVMe (up to 36 bays), using front, mid-tray, and rear drive cages.
• Interfaces & types: SAS (24G, backward-compatible to 12G), SATA (6G), and NVMe (U.3 and E3.S, PCIe Gen5) — available as both hard drives (HDD) and solid-state drives (SSD).
• Capacities: SSDs from 240GB up to 15.36TB (SFF) or 30.72TB (E3.S EDSFF); HDDs up to 2.4TB (SFF) or 26TB (LFF). High-capacity E3.S NVMe SSDs are available for the highest flash density.
• Carriers: HPE Basic Carrier (BC) for SFF SAS/SATA/U.3 NVMe, low-profile carrier for LFF SAS/SATA, and E3.S carrier (EC) for EDSFF NVMe.
• Boot & RAID: optional NS204i-u v2 boot device (two M.2 NVMe SSDs in RAID 1; front, rear, or internal), embedded Intel® VROC for NVMe, and HPE MR-series Smart Array / TriMode controllers including the PCIe Gen5 MR932i-p.

Before you order, match the drive to your chassis and backplane. The DL380 Gen12 ships in SFF, LFF, and EDSFF configurations with different backplanes, so confirm three things: the form factor (2.5-inch SFF, 3.5-inch LFF, or E3.S EDSFF), the interface your backplane supports (SAS, SATA, or NVMe), and the correct carrier. TriMode (U.3) backplanes accept SAS, SATA, or NVMe in the same bay, but the LFF chassis is SAS/SATA only and does not support NVMe.

Drive Form Factors, Interfaces & Carriers

The DL380 Gen12 offers extensive storage scale in 2U. SFF (2.5-inch) scales to 24 front bays plus up to 6 rear (30 total) and accepts SAS, SATA, or U.3 NVMe on TriMode backplanes. LFF (3.5-inch) scales to 20 bays across front, mid-tray, and rear cages for high-capacity SAS/SATA HDDs (NVMe is not supported in LFF). EDSFF (E3.S) reaches up to 36 PCIe Gen5 NVMe drives for maximum flash density.

On TriMode (U.3) backplanes, a single bay can take a SAS, SATA, or NVMe drive, giving you room to mix media as needs change. SFF drives use HPE's Basic Carrier (BC) — the same carrier introduced with Gen11, and distinct from the Smart Carrier used on Gen10 and earlier servers — so confirm your drives ship in the correct carrier for proper fit, hot-plug operation, and status-LED function. For the full drive cage, backplane, and capacity matrix, see the official HPE QuickSpecs:

HPE ProLiant Compute DL380 Gen12 QuickSpecs (PDF)

DL380 Gen12 Drive FAQ

What drives are compatible with the HPE DL380 Gen12?
Hot-plug SAS, SATA, and NVMe drives in 2.5-inch SFF, 3.5-inch LFF, or E3.S EDSFF form factors, as both HDDs and SSDs. The drive's form factor and interface must match your installed chassis and backplane, and SFF drives should use the Basic Carrier.

How many drives does the DL380 Gen12 support?
Up to 30 SFF (2.5-inch) drives (24 front plus up to 6 rear), up to 20 LFF (3.5-inch) drives, or up to 36 E3.S EDSFF NVMe drives, using front, mid-tray, and rear drive cages.

Does the DL380 Gen12 support NVMe SSDs?
Yes. It supports U.3 NVMe in 2.5-inch bays (on TriMode/U.3 backplanes) and up to 36 E3.S EDSFF NVMe drives, both over PCIe Gen5. The LFF chassis is SAS/SATA only and does not accept NVMe.

What carrier do DL380 Gen12 drives use?
2.5-inch drives use HPE's Basic Carrier (BC), the same carrier introduced with Gen11 and distinct from the Smart Carrier used on Gen10 and earlier servers. Be sure any drive you buy ships in the correct carrier so it seats properly and reports drive status correctly.

✅ Need help finding the right DL380 Gen12 drive? Browse our full selection above, or contact our HPE specialists for a guaranteed-compatible recommendation.

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