HPE ProLiant DL380 Gen12 Processors
Genuine HPE-qualified Intel Xeon 6 processors for the HPE ProLiant DL380 Gen12, new and refurbished, alongside the heat sink kits the platform's cooling tiers depend on. Gen12 gives the DL380 two distinct CPU families in one socket: Efficient-core (E-core) models up to 144 cores for throughput-per-watt, and Performance-core (P-core) models up to 86 cores for per-core speed.
DL380 Gen12 Processor Specifications
- Family: Intel Xeon 6 — E-core and P-core lines, one or two sockets
- E-core range: 64 cores / 2.4GHz (6710E) up to 144 cores (6766E at 1.9GHz, 6780E at 2.2GHz) — 205W–330W
- P-core range: 8 cores / 3.5GHz (6507P) up to 86 cores / 2.0GHz (6787P) — 150W–350W, including Mainline and Socket-Scalable lines
- Memory support: DDR5 at up to 6400 MT/s — per-model: most P-core CPUs run 6400, some E-core models 5600
- Cooling: Standard, Performance, High Performance, and Max Performance heat sink kits — matched to CPU TDP and configuration; direct liquid cooling (DLC) available on CTO builds with iLO 7 leak detection
Processors ship without heat sinks. Order the heat sink kit for your cooling tier — Standard, Performance, High Performance, or Max Performance — keep both installed CPUs the identical model, and check the CPU's DDR5 column: it sets whether your memory runs at 6400 or 5600 MT/s.
Which Intel Xeon 6 processors does the DL380 Gen12 support?
| Processor | Type | Cores | Base clock | TDP |
|---|---|---|---|---|
| Intel Xeon 6507P | P-core | 8 | 3.5GHz | 150W |
| Intel Xeon 6725P | P-core | 16 | 3.7GHz | 235W |
| Intel Xeon 6732P | P-core | 32 | 3.8GHz | 350W |
| Intel Xeon 6747P | P-core | 48 | 2.7GHz | 330W |
| Intel Xeon 6787P | P-core | 86 | 2.0GHz | 350W |
| Intel Xeon 6710E | E-core | 64 | 2.4GHz | 205W |
| Intel Xeon 6746E | E-core | 112 | 2.0GHz | 250W |
| Intel Xeon 6780E | E-core | 144 | 2.2GHz | 330W |
High clocks with low core counts (6507P, 6714P) suit per-core database licensing; the 64–144 core parts are consolidation and cloud-native engines. Two 144-core 6780E processors put 288 cores in 2U. Processors ship without heat sinks — add the kit that matches your cooling tier.
Choosing the Right DL380 Gen12 Processors
- Pick the core type for the workload: P-core for databases, VDI, and licensed software; E-core for scale-out, web, and containerized services where cores-per-watt wins.
- Installed processors must match — buy pairs of the same model, and match the existing CPU exactly when adding a second.
- Heat sinks are separate parts: Standard, Performance, High Performance, and Max Performance kits map to TDP and chassis — GPU builds specifically require the high-performance tier.
- Check the memory speed column: the CPU sets the platform's DDR5 ceiling (6400 vs 5600 MT/s on some E-core models) — pair your memory choice with it.
Complete Your DL380 Gen12 Build
Every added processor unlocks 16 more DIMM slots: see DL380 Gen12 memory, then drives, storage controllers, networking, and power supplies, or the full DL380 Gen12 parts page. Previous generation: DL380 Gen11 processors. Catalog-wide: HPE parts by server model.
DL380 Gen12 Processors FAQ
What processors does the HPE ProLiant DL380 Gen12 support?
Intel Xeon 6 - both Efficient-core models (64 to 144 cores, such as the 6710E and 6780E) and Performance-core models (8 to 86 cores, from the 8-core 6507P at 3.5GHz to the 86-core 6787P), in one- or two-socket configurations.
What is the maximum core count of the DL380 Gen12?
288 cores - two Intel Xeon 6780E processors at 144 E-cores each. On the P-core side, two 86-core 6787P processors deliver 172 cores with higher per-core performance.
What is the difference between Xeon 6 E-core and P-core processors?
E-core (Efficient-core) models maximize cores per watt for scale-out and cloud-native workloads - up to 144 cores at 205-330W. P-core (Performance-core) models deliver stronger per-core performance for databases and licensed software - up to 86 cores, with clocks up to 3.8GHz. The DL380 Gen12 supports both; installed CPUs must be the same model.
Do DL380 Gen12 processors come with heat sinks?
No - heat sinks are separate kits in four tiers: Standard, Performance, High Performance, and Max Performance. Order the tier matching your CPU's TDP and configuration; GPU builds require the high-performance tier.
Can the DL380 Gen12 run with one processor?
Yes - single-processor configurations are fully supported, exposing 16 DIMM slots and the primary riser's PCIe slots. A second processor is required for the secondary and tertiary risers and doubles the memory slots to 32.
Which DL380 Gen12 processor is best for database licensing?
The 8-core Intel Xeon 6507P at 3.5GHz base - the highest clock with the lowest core count in the lineup. The 16-core 6725P at 3.7GHz is the step up when eight cores per socket isn't enough.
✅ Looking for a specific DL380 Gen12 processor? Browse our full selection below.
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