HPE ProLiant DL385 Gen10 Plus v2 Processors
Genuine HPE-qualified AMD EPYC processors for the HPE ProLiant DL385 Gen10 Plus v2, new and refurbished, with the heat sink and fan kits they need. This 2U platform takes one or two EPYC 7003 Series CPUs, and HPE processor kits ship without a heat sink or fans.
DL385 Gen10 Plus v2 Processor Specifications
- Families: AMD EPYC 7003 Series from 8 to 64 cores, plus three 7002 Series carry-overs (7402, 7302, 7252)
- Sockets: one or two — mixing two different processor models is not allowed
- TDP range: 120W (7203, 7252) up to 280W (7763, 75F3, 7773X, 7573X), with chassis and ambient setting the ceiling
- Large cache: the 7003X parts (7773X, 7573X, 7473X, 7373X) carry 768MB of L3 cache against 128–256MB elsewhere in the line
- Memory reach: every EPYC listed supports up to 4TB per socket at up to 3200 MT/s
- Cooling: 155W and below take the Standard Heat Sink and Standard Fan kits; above 155W requires the High Performance Heat Sink Kit and the Max Performance Fan Kit
Order the heat sink and fan kit with the processor. HPE processor kits for this server ship without either. Parts rated 155W and below take the Standard Heat Sink and Standard Fan kits; anything above 155W requires the High Performance Heat Sink Kit and the Max Performance Fan Kit.
Which AMD EPYC processors fit the DL385 Gen10 Plus v2?
| Class | Examples | Best for |
|---|---|---|
| Core-dense 7003 | 7763 (64C/280W), 7713 (64C/225W), 7663 (56C/240W), 7643 (48C/225W) | Virtualization density |
| Mainstream 7003 | 7543, 7513, 7453, 7443, 7413, 7343, 7313, 7303, 7203 | General-purpose 2U builds |
| Frequency-optimized (F) | 75F3 (32C/2.95GHz), 74F3 (24C/3.2GHz), 73F3 (16C/3.5GHz), 72F3 (8C/3.7GHz) | Per-core licensed databases |
| Large-cache (X) | 7773X (64C), 7573X (32C), 7473X (24C), 7373X (16C) — 768MB L3 | Cache-bound technical and simulation workloads |
| 7002 Series carry-overs | 7402 (24C/180W), 7302 (16C/155W), 7252 (8C/120W) | Matching an existing EPYC 7002 estate |
Two 64-core parts put 128 cores in 2U. The 155W line is the buying threshold: below it the Standard kits apply, above it the High Performance Heat Sink Kit and Max Performance Fan Kit are mandatory.
Choosing the Right DL385 Gen10 Plus v2 Processors
- Both sockets must hold the same model — HPE's rule is to order the identical -B21 processor kit for the second socket.
- The second processor unlocks more than cores: the full 32 DIMM slots, the secondary and tertiary risers, and the step from three PCIe slots to eight — see DL385 Gen10 Plus v2 memory.
- Budget for cooling in the same order: processor kits include neither heat sink nor fans.
- Respect the thermal envelope: 280W parts need specific chassis and ambient combinations, and the 12+4 LFF and 24+8 SFF layouts cap at 225W (turbo to 240W).
Complete Your DL385 Gen10 Plus v2 Build
A second processor unlocks 16 more DIMM slots: see DL385 Gen10 Plus v2 memory, then drives, storage controllers, networking adapters, and power supplies, or the full DL385 Gen10 Plus v2 parts page. Neighboring models: DL385 Gen10 Plus processors, DL385 Gen11 processors, and the single-socket DL325 Gen10 Plus v2 processors. Catalog-wide: HPE parts by server model.
DL385 Gen10 Plus v2 Processors FAQ
What processors does the HPE ProLiant DL385 Gen10 Plus v2 support?
AMD EPYC 7003 Series processors from the 8-core 7203 to the 64-core 7763, including the F-series high-frequency parts and the 768MB-cache 7003X models, plus the EPYC 7402, 7302, and 7252 from the 7002 Series. One or two may be installed.
What is the maximum core count of the DL385 Gen10 Plus v2?
128 cores - two 64-core processors such as the EPYC 7763, 7713, or 7773X.
Do DL385 Gen10 Plus v2 processor kits include a heat sink?
No. The QuickSpecs note on every processor kit says it does not include a fan kit or a heat sink kit. Order the Standard Heat Sink and Standard Fan kits for 155W-and-below CPUs, or the High Performance Heat Sink Kit and Max Performance Fan Kit above 155W.
Can I mix two different EPYC models in one DL385 Gen10 Plus v2?
No - HPE states that mixing two different processor models is not allowed. When adding a second CPU, order the same part number as the one already installed.
What does adding a second processor unlock on the DL385 Gen10 Plus v2?
The second bank of 16 DIMM slots for 32 total, the secondary and tertiary risers, and the expansion from three PCIe slots to as many as eight.
What is different about the EPYC 7773X and 7573X processors?
They are the 7003X large-cache parts: 768MB of L3 cache versus 128MB to 256MB on the rest of the line. They are 280W CPUs with restricted chassis and ambient support, and they require the Max Performance Fan Kit and High Performance Heat Sink Kit.
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