HPE ProLiant DL385 Gen11 Memory

Scale your HPE ProLiant DL385 Gen11 server with genuine DDR5 ECC Registered (RDIMM) memory. Built for this dual-socket, 2U AMD EPYC server, these DL385 Gen11 memory modules deliver the bandwidth, capacity, and reliability your most demanding virtualization, database, and AI workloads require — with guaranteed compatibility.

DL385 Gen11 Memory Specifications

• Memory type: DDR5 ECC Registered (RDIMM), with 3DS RDIMM for the highest capacities. The DL385 Gen11 does not support LRDIMM, UDIMM, persistent memory, or non-ECC memory.
• Speeds: Up to 4800 MT/s with 4th Gen AMD EPYC™ 9004 (Genoa). 5th Gen AMD EPYC™ 9005 (Turin) uses DDR5-6400 modules, which operate at up to 6000 MT/s on this dual-socket platform.
• Capacities: 16GB, 32GB, 64GB, 128GB, and 256GB modules.
• Maximum memory: Up to 6TB across 24 DIMM slots with two processors installed — 12 DIMM slots per processor (one DIMM per channel) across all 24 AMD EPYC memory channels.

Before you order, match your memory to your CPU. The DL385 Gen11 runs either 4th Gen AMD EPYC™ 9004 “Genoa” (DDR5-4800) or 5th Gen AMD EPYC™ 9005 “Turin” (DDR5-6400) processors, and your CPU sets the memory speed. Per HPE, faster DIMMs paired with a CPU that supports a lower speed run at the slower speed, and mixing slower and faster DIMMs forces the entire system to the slowest module. As a dual-socket server, install matching DIMMs on both processors and keep memory balanced across them for full bandwidth.

Memory Population Rules

For best performance, install matched DDR5 RDIMM kits, fill the white DIMM slots first, and balance DIMMs evenly across both processors. Each processor accepts DIMMs in quantities of 1, 2, 4, 6, 8, 10, or 12, and populating all 24 channels (12 per CPU) unlocks full bandwidth. See HPE's AMD EPYC population guidelines here:

HPE Memory Population Rules — AMD EPYC (PDF)

DL385 Gen11 Memory FAQ

What type of memory does the HPE DL385 Gen11 use?
DDR5 ECC Registered (RDIMM) memory, with 3DS RDIMM used for the largest (256GB) modules. LRDIMM, unbuffered (UDIMM), and persistent memory are not supported. The same RDIMM type works with both 4th Gen (Genoa) and 5th Gen (Turin) AMD EPYC CPUs.

How much RAM can the DL385 Gen11 hold?
Up to 6TB with two processors installed, using 24 x 256GB DDR5 RDIMMs (12 DIMM slots per processor). With only one processor installed, half the slots are active — 12 DIMMs for up to 3TB.

What is the maximum memory speed?
It depends on your processor: 4th Gen AMD EPYC 9004 (Genoa) runs DDR5-4800. 5th Gen AMD EPYC 9005 (Turin) uses DDR5-6400 modules, which operate at up to 6000 MT/s on this dual-socket platform. For maximum bandwidth, populate all 24 channels.

Should I buy DDR5-4800 or DDR5-6400 memory?
Match the speed grade to your CPU generation — DDR5-4800 for 4th Gen EPYC 9004 (Genoa), or DDR5-6400 for 5th Gen EPYC 9005 (Turin), which run at up to 6000 MT/s here. The server runs all memory at the slowest installed speed, so keep speed grades consistent and balanced across both sockets. Both are the same DDR5 ECC Registered (RDIMM) type. Not sure which CPU you have? Check the processor model in HPE iLO or your order details, or contact our team.

✅ Looking for a specific DL385 Gen11 memory module? Browse our full selection above, or contact our HPE specialists for a guaranteed-compatible recommendation.

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