HPE ProLiant DL385 Gen10 Plus Processors
Genuine HPE-qualified AMD EPYC processors for the HPE ProLiant DL385 Gen10 Plus, new and refurbished, alongside heat sink and fan kits. The platform takes one or two EPYC 7002 Series CPUs from 8 to 64 cores — and HPE states that EPYC 7003 Series processors cannot be supported in this server.
DL385 Gen10 Plus Processor Specifications
- Families: AMD EPYC 7002 Series in one or two sockets; the QuickSpecs also list EPYC 7001 Series support and rule out EPYC 7003
- Range: 8 cores (EPYC 7252, 7262, 7F32) through 64 cores (EPYC 7662, 7702, 7742), with 64MB to 256MB of cache
- TDP: 120W to 240W — the 24-core EPYC 7F72 tops the frequency-optimized line at 240W
- Memory support: every listed processor handles up to 4TB and DDR4 speeds up to 3200 MT/s
- Cooling: processors above 180W ship with the High Performance heat sink and require the Maximum Performance fan kit
- Ordering: the first CPU is the -L21 kit; the second is the matching -B21 kit, which also brings two more fans
Both sockets must match. HPE does not allow two different processor models in a DL385 Gen10 Plus, so pair the first -L21 kit with the identical -B21 kit for socket two — and anything above 180W needs the High Performance heat sink plus the Maximum Performance fan kit.
Which processors does the DL385 Gen10 Plus support?
| Tier | Examples | Best for |
|---|---|---|
| Frequency-optimized | EPYC 7F32 (8C), 7F52 (16C, 3.5GHz), 7F72 (24C, 3.3GHz) | Per-core licensed databases |
| Mainstream | EPYC 7302 (16C), 7402 (24C), 7502 and 7542 (32C) | General virtualization and mixed workloads |
| High core count | EPYC 7642 (48C), 7702 and 7742 (64C) | Consolidation density — 128 cores in 2U |
Two 64-core EPYC 7742 processors put 128 cores in 2U. Watch the thermal envelope on the way up: anything above 180W needs the High Performance heat sink and the Maximum Performance fan kit, and a 4 LFF mid-tray build caps processor selection at 200W.
Choosing the Right DL385 Gen10 Plus Processors
- Both sockets must hold the identical model — HPE does not allow mixing two different processor models in this server.
- The second CPU unlocks more than cores: 16 additional DIMM slots and the secondary and tertiary risers carrying PCIe slots 4 through 8 all depend on it.
- The 7F-series parts are the licensing play — 8, 16, and 24 cores at 3.3GHz base and above, with up to 256MB of cache, when the software bill is charged per core.
- Plan cooling with the CPU: above 180W the High Performance heat sink and Maximum Performance fan kit are both required, and 4 LFF mid-tray configurations limit you to 200W.
- The processor sets the memory ceiling — see DL385 Gen10 Plus memory for the DDR4-3200 population rules.
Complete Your DL385 Gen10 Plus Build
Every added processor unlocks 16 more DIMM slots: see DL385 Gen10 Plus memory, then drives, storage controllers, networking, and power supplies, or the full DL385 Gen10 Plus parts page. Neighboring platforms: DL385 Gen10 processors and DL385 Gen10 Plus v2 processors. Catalog-wide: HPE parts by server model.
DL385 Gen10 Plus Processors FAQ
What processors does the HPE ProLiant DL385 Gen10 Plus support?
One or two AMD EPYC 7002 Series processors, from 8 cores to 64, in TDPs from 120W to 240W. The QuickSpecs also list EPYC 7001 Series support and state that AMD EPYC 7003 Series processors cannot be supported in this server system.
Can I install an EPYC 7003 processor in a DL385 Gen10 Plus?
No. HPE states plainly that AMD EPYC 7003 Series processors cannot be supported in this server system - the DL385 Gen10 Plus supports the EPYC 7001 and 7002 Series only.
What is the maximum core count of the DL385 Gen10 Plus?
128 cores - two 64-core EPYC processors. The QuickSpecs list three 64-core parts for this platform: the 7742 at 2.25GHz base, the 7662 at 2.0GHz, and the 7702 at 2.0GHz.
What is the difference between the -L21 and -B21 processor kits?
Order position. The -L21 kit is the first processor shipped with the server, and the matching -B21 kit is the second processor, which also includes two additional fans for factory or field installation. Both processors must be the same model.
Do DL385 Gen10 Plus processor kits include a heat sink?
Yes. HPE's processor option kits ship with a heat sink - the standard type on lower-TDP parts and the High Performance type on the higher ones. Processors above 180W use the High Performance heat sink and also require the Maximum Performance fan kit, which supplies all six fans.
What does adding a second processor to a DL385 Gen10 Plus unlock?
16 more DIMM slots for 32 in total, the secondary and tertiary risers carrying PCIe slots 4 through 8, and two extra fans that ship inside the -B21 kit. The second CPU has to be identical to the first.
✅ Looking for a specific DL385 Gen10 Plus processor? Browse our full selection below.
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