HPE ProLiant DL385 Gen11 Processors
Genuine HPE-qualified AMD EPYC processors for the HPE ProLiant DL385 Gen11, new and refurbished, alongside the heat sink kits they need. The platform takes two generations: 4th Generation EPYC 9004 (up to 128 cores, DDR5-4800) and 5th Generation EPYC 9005 (up to 160 cores, DDR5-6400).
DL385 Gen11 Processor Specifications
- Families: 4th Gen AMD EPYC 9004 Series (16 to 128 cores) and 5th Gen AMD EPYC 9005 Series (8 to 160 cores), one or two sockets
- Frequency and cache parts: F-series models reach 5.0 GHz on 5th Gen; 4th Gen X-series parts carry up to 1,150MB of cache
- Memory support: the generation sets the DDR5 grade — 4800 MT/s on 9004, 6400 MT/s on 9005, 3TB per socket
- Power: default cTDP of 125W to 400W
- Interconnect: 160 PCIe 5.0 lanes with two sockets, over a 3xGMI processor interconnect
- Cooling: kits ship without heat sinks or fans — Standard, Performance, and Max Performance 2U heat sink kits match the TDP band
Order the heat sink and fans with the processor. HPE CPU kits ship without either, and the TDP band decides the kit — Standard up to 240W, Performance from 240W to 320W, Max Performance at 320W and above. Both sockets must hold the identical processor model.
Which processors does the DL385 Gen11 support?
| Family | Cores | Memory grade | Example models |
|---|---|---|---|
| 4th Gen EPYC 9004 | 16 to 128 | DDR5-4800 | 9124, 9354, 9654, 9754 |
| 4th Gen EPYC 9004X | 16 to 96 | DDR5-4800 | 9184X, 9384X, 9684X (1,150MB cache) |
| 5th Gen EPYC 9005 | 8 to 160 | DDR5-6400 | 9015, 9355, 9655, 9845 |
| 5th Gen EPYC 9005 F-series | 16 to 64 | DDR5-6400 | 9175F, 9375F, 9575F (to 5.0 GHz) |
Two 160-core EPYC 9845 processors put 320 cores in 2U. Processors ship without cooling: up to 240W takes the Standard 2U heat sink and Standard fans, 240W to 320W the Performance heat sink and Performance fans, and 320W and above the Max Performance heat sink.
Choosing the Right DL385 Gen11 Processors
- Both processors must be identical — HPE does not allow mixing two processor models, so match the existing -B21 part number when adding a second CPU.
- Buy the heat sink and fan kit with the processor: the TDP band picks the heat sink kit, and Gen11 fan kits hold one fan each, so a two-socket build needs six.
- The second processor unlocks more than cores: 12 more DIMM slots, the secondary and tertiary risers, the OCP x16 two-slot upgrade, and all 160 PCIe 5.0 lanes.
- Watch chassis interactions: a processor above 300W rules out the mid drive cage, and Direct Liquid Cooling needs two processors.
- Fan noise after a CPU swap usually means the wrong fan or heat sink kit — see our guide to excessive fan noise in HPE ProLiant servers.
Complete Your DL385 Gen11 Build
A second processor unlocks 12 more DIMM slots: see DL385 Gen11 memory, then drives, storage controllers, networking, and power supplies, or the full DL385 Gen11 parts page. Related platforms: DL385 Gen10 Plus v2 processors, DL325 Gen11 processors, and DL380 Gen11 processors. Catalog-wide: HPE parts by server model.
DL385 Gen11 Processors FAQ
What processors does the HPE ProLiant DL385 Gen11 support?
4th Generation AMD EPYC 9004 Series processors from 16 to 128 cores at DDR5-4800, and 5th Generation AMD EPYC 9005 Series processors from 8 to 160 cores at DDR5-6400, in one- or two-socket configurations.
What is the maximum core count of the DL385 Gen11?
320 cores - two 160-core EPYC 9845 processors. On 4th Gen the 128-core EPYC 9754 tops the line, for 256 cores across two sockets.
Do DL385 Gen11 processors come with heat sinks?
No. HPE processor kits ship without heat sinks and fans. Order the kit that matches the CPU's TDP band: Standard up to 240W, Performance from 240W to 320W, and Max Performance at 320W and above.
Can I mix 4th Gen and 5th Gen EPYC processors in one DL385 Gen11?
No. HPE does not allow mixing two different processor models at all, so both sockets must hold the same part number. The generations also differ in supported memory speed, so the mix would make no sense even if it were permitted.
What does adding a second processor to a DL385 Gen11 unlock?
12 more DIMM slots for 24 total, the secondary and tertiary PCIe risers, the two-slot OCP x16 upgrade, and the full 160 PCIe 5.0 lanes - plus the cores.
Which DL385 Gen11 processor suits per-core software licensing?
The F-series frequency-optimized models. They run 16 to 64 cores at up to 5.0 GHz on 5th Gen, delivering maximum per-core performance with the fewest licensed cores.
✅ Looking for a specific DL385 Gen11 processor? Browse our full selection below.
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